Ger­MIS (Ger­man Mar­row Donor Infor­ma­ti­on Sys­tem) is a ful­ly auto­ma­ted elec­tro­nic infor­ma­ti­on net­work used in the search for an unre­la­ted donor. Ger­MIS per­mits data to be exch­an­ged as quick­ly and effec­tively as pos­si­ble bet­ween the faci­li­ties in Ger­ma­ny that play a signi­fi­cant role in sear­ching for donors. The cur­rent Ger­MIS per­mits decen­tra­li­zed data­ba­ses at search cen­ters and donor cen­ters to com­mu­ni­ca­te asyn­chro­nous­ly with the cen­tra­li­zed sys­tem at the ZKRD via encryp­ted and spe­cial­ly secu­red protocols.